Version 2.6.9 (29th June 2008)

1. Streamlined installation procedure.
2. Corrected message in Kruskal-Wallis test when there are no ties across the samples.

Version 2.6.8 (1st June 2008)

1. Improvements to help system.
2. Menu layout change: 'miscellaneous' renamed 'clinical epidemiology'.
3. Improved copy and paste to/from reports.

Version 2.6.7 (26th April 2008)

1. Fixed the display of the graph scale dialog box under Vista SP1.
2. Updated installer system to work better with Vista SP1.
3. Updated group split and combine to allow for explicit use of missing data categories.
4.  Improved navigation and layout of help system.
5.  Improved speed of graphics operations.

Version 2.6.6 (3rd February 2008)

1. Fixed the automatic launching of StatsDirect, with a worksheet loaded, when clicking on the worksheet name in Windows Explorer in Vista.

Version 2.6.5 (4th September 2007)

1. Updated the treatment of empty cells to make it as close as possible to that of cells with explicit missing data marked with an asterisk.

Version 2.6.4 (23rd August 2007)

1. Kappa error correction updated to allow for absence of ratings for a given subject.
2. Added automatic padding of blank cells, as missing data, at the ends of columns, where relevant.

Version 2.6.3 (19th July 2007)

1. Changed diagnostic odds ratio from a conditional maximum likelihood estimate to the raw odds ratio, with confidence limits via conditional maximum likelihood.
2. Improved the appearance of some of the dialog boxes when running under Vista.

Version 2.6.2 (17th February 2007)

1. Updated help file format to HTML Help for compatibility with Windows Vista.
2. Replaced installer.

Version 2.6.1 (1st January 2007)

1. Replaced chart maker with a more powerful charting tool.
2. Updated font control method for charts.
3. Added more diagnostic information for poorly fitting Cox regression models.
4. Updated block randomisation algorithm to vary between 2 and 4 times the number of treatments as a random block size.
5. More traps for illegal inputs added to the 2xk likelihood ratio function..

Version 2.5.7 (6th August 2006)

1. Correction of typographical errors in sample size menu and formula for log standardised rate ratio variance.
2. Enhanced appearance of help text.
3. Enhanced data input for Latin square test.

Version 2.5.6 (15th April 2006)

1. Categorise function updated to replace the comma separator of data ranges with a semi-colon in order to allow comma-delimited decimal numbers to be used.
2. Correction to formula in the help file for proportion meta-analysis.
3. Correction to plot labels for Cox regression binary predictors.

Version 2.5.5 (5th February 2006)

1. Updated Cox regression to handle larger datasets and provide more precise estimates.
2. Added log-log plots to Cox regression for assessment of the proportional hazards assumption.
3. Added group-specific survival and hazard estimates from binary predictors in Cox regression.
4. Re-written handling of classifier variables in Cox regression to be consistent with other regression functions.
5. Added the option (default) to centre continuous predictors in Cox regression.
6. Clarified the output and interface of Cox regression.

Version 2.5.4 (21st January 2006)

1. Updated confidence interval calculation for meta-analysis I² to use the non-central chi-square distribution method of Hedges and Pigott when the exact methods option is selected.
2. Fixed problem with Cox regression and very large datasets.
3. Updated dummy variable function to skip missing data.

Version 2.5.3 (17th January 2006)

1. Added the option to delay continuity correction until after the fixed effects Mantel-Haenszel pooled odds ratio computations.

Version 2.5.2 (8th January 2006)

1. Added Harbord (modified Egger) bias detection test to meta-analysis.
2. Reduced verbosity of meta-analysis outputs.

Version 2.5.1 (5th January 2006)

1. Added meta-analysis options menu to allow choice of continuity correction and weights diagnostics.
2. Extended the choice of continuity correction in meta-analysis with sparse tables from 0.5 (Haldane) to any other constant or balanced (Sweeting et al.).
3. Added I² to the heterogeneity diagnostics in meta-analysis.
4. Updated the handling of sparse tables in meta-analysis.
5. Added meta-analysis function for proportions.
6. Added diagnostic odds ratio to diagnostic test function.
7. Re-scaled the weight indicator in Forest plots.
8. Improved handling of sparse data in risk-ratio confidence intervals.
9. Improved clarity of all meta-analysis reports.
10. Extended sample size for survival studies to allow multiple controls per experimental subject.

Version 2.4.6 (16th October 2005)

1. Correction to Kappa inter-rater agreement with some missing data categories.
2. Procedures expecting equal numbers of observations per variable now accept unequal length columns and read to the last row of the shortest column across all, instead of demanding equal length columns.
3. Error trap for repeated two way ANOVA in plain two way ANOVA.
4. Improved handling of large numbers of observations in nonparametric regression.
    

Version 2.4.5 (30th May 2005)

1. Kappa inter-rater agreement updated to exclude missing data categories.
2. Error handling in paired t-test improved for extreme data.
3. Error handling for missing or corrupt system files at start-up improved.
4. Cut-off point for best sensitivity and specificity now shown with a large plot symbol in ROC curves.
5. Correction to Kappa inter-rater agreement with some missing data categories.
    

Version 2.4.4 (14th February 2005)

1. Option added to crosstabs to expand asymmetrical tables into symmetrical alternatives with empty columns or rows.
2. Error handling in r by c table functions extended to handle empty rows or columns.
3. Kappa inter-rater agreement test updated to make asymmetrical tables symmetrical when there are two raters.
4. More powerful option to switch the StatsDirect Excel link on/off, under Tools_Setup Tools.

Version 2.4.3 (17th December 2004)

1. Improved error handling in meta-analysis (incidence rate difference and bias detection).

Version 2.4.1 (14th August 2004)

1. Updated system runtime libraries.
2. Maximum difference now plotted instead of mean difference in agreement analysis for more than two groups.
3. All graphics options now saving properly between sessions.
4. Impossible Brookmeyer Crowley confidence limits suppressed in Kaplan Meier.
5. Fixed occasional problem with median difference confidence interval in the Wilcoxon signed ranks function.
6. Added manual control over the link with Excel via the Tools_Setup Tools menu.

Version 2.3.8 (17th April 2004)

1. Labelling for McNemar test improved.
2. Hybrid Fisher-Freeman-Halton P calculation enabled.
3. Most prevalent category indication added to the dummy/indicator variable options.

Version 2.3.7 (21st January 2004)

1. Internal optimisations.
2. Confidence interval with Mann-Whitney test changed to use quicker approximation with large numbers.
3. Corrected under-estimation of Fisher-Freeman-Halton probability with some contingency tables.
4. Improved concealment of context-sensitive help codes.
5. Population attributable risk display suppressed for negative values

Version 2.3.6 (2nd January 2004)

1. Improved graphics export.
2. Clarified row and column score labels and input in the generalized Cochran-Mantel-Haenszel test.

Version 2.3.5 (22nd November 2003)

1. Excel-link add-in moved from library to start-up path for better operation under Excel 2003.
2. Monte Carlo simulation added to the abridged life table.

Version 2.3.4 (26th October 2003)

1. Export facility for individual graphics in reports.
2. Corrected missing data handling in categorise function.
3. Added a fill series function to the data menu.

Version 2.3.3 (15th September 2003)

1. Improved ROC curves.
2. Updated crosstabs to skip missing data.

Version 2.3.2 (23rd August 2003)

1. Updated block randomisation to be able to use block sizes selected at random from 2, 3 or 4 times the number of treatment groups.

Version 2.3.1 (29th July 2003)

1. Improved handling of graphics for very large data sets.
2. Extended selection of data by group identifier to multiple group identifiers in most functions.
3. Improved and extended random number generators for simulation work.
4. Partial correlation coefficients added to the multiple linear regression standard output.
5. Interpolation function in multiple linear regression renamed prediction and improved to pre-load its predictor values with those required to calculate the least squares mean of the outcome.
6. Descriptive statistics improved to allow for weights, more quantiles and a new quantile definition, which can be weighted, added as the default method (old method can be selected as an option).
7. Extended range of default confidence interval levels.
8. Added confidence intervals and prediction intervals for predicted responses from logistic regression models.
9. Improved categorise function for grouping data.

Version 2.2.9 (15th June 2003)

1. Updated funnel plots to make the confidence interval cone optional.
2. Corrected area under curve in logistic regression with certain data patterns.

Version 2.2.8 (3rd May 2003)

1. Updated security certificates.
2. Corrected category enumeration for kappa with some data.

Version 2.2.7 (6th April 2003)

1. Added abridged life table.
2. Corrected area under some ROC curves in logistic regression classification.
3. Enhanced principal components analysis with scale reversal detection and expanded help.
4. Updated screen input version of kappa (two rater) and added further error traps to kappa calculations.

Version 2.2.5 (9th March 2003)

1. Power results now state significance level at which they are calculated on the observed effect and sample size.
2. Added automatic checking for updates via Internet.

Version 2.2.4 (25th February 2003)

1. Improved handling of zero frequencies in relative risk meta-analysis.
2. Added a categorise data function.
3. Multiple histograms can now be plotted at once from multiple column selections.
4. Extended maximum size of spread plot and box & whisker plot.
5. Logistic regression classification function now gives area under ROC curve.
6. Extended crosstabs to three factors, i.e. stratified two way tables.
7. Added sample size for Pearson's correlation.
8. Added power for correlation test to simple linear regression and correlation output.
9. Added generalised Cochrane-Mantel-Haenszel tests to three factor crosstabs analysis.
10. Extended Kappa to cope with unbalanced responses for two raters, and methods for more than two raters.
11. Added tabulate and detabulate functions to data menu (two way crosstabs and table expansion directly to worksheet).
12. Expanded and reorganised menus.
13. Added fixed and random block randomisation.
14. Enhanced interfaces for improved workflow.

Version 2.2.3 (16th October 2002)

1. Added power calculations to risk (prospective and retrospective) and t-test functions
2. Further improvements to help system.
3. Improved stability of Fisher-Freeman-Halton P value computation via crosstabs.
4. Fixed problem running under Windows XP Home Edition without Excel installed.

Version 2.2.2 (19th September 2002)

1. Improved selection by group identifier for two way anova and Friedman.
2. Further improvements to help system.
3. Added reboot at end of installation.

Version 2.2.1 (1st September 2002)

1. Improved help system.

Version 2.2.0 (27th August 2002)

1. Added Poisson regression.
2. Improved efficiency of most regression functions.
3. Updated exact P values from Spearman's rho with small samples.
4. Improved dummy variable generator with option to define the category dropped.
5. Extended crosstabs to allow for multiple categories to be selected against a reference category.
6. Extended calculator functions.
7. New random number generator: Mersenne Twister.
8. Updated discrete data handling in logit, probit and angular transformations to ignore sign of input data.
9. Excel add-in now digitally signed to comply with high macro security.
10. Extensive review of all code and new optimisations.

Version 2.0.1 (17th June 2002)

1. Revised forest plots to publication standard.
2. Revised meta-analysis bias detection plots to conventional style.
3. Added L'Abbé plots to meta-analysis.
4. Improved standardized rate ratio plot.
5. Fixed categorical predictor warning in regression functions.
6. Confidence intervals for coefficients in multiple linear regression added to parameter detail output.
7. Further refinements to graphics generally.
8. Updated help.

Version 2.0.0 (8th June 2002)

1. Added option to translate formulae in data block rotation.
2. Fixed untitled column reference label.
3. Improved handling of huge workbooks.
4. Added conditional logistic regression function.
5. Improved dialogs and options in graphics functions.
6. Added control plots.
7. Added standardized rate comparison functions.
8. Updated dummy variable function to be compatible with commonly used schemes.
9. New license key mechanism, backwards compatible with old keys until June 2004.
10. Multiple improvements to the user interface.
11. F9 key shortcut for column data summary in workbook.
12. Improved crosstabs.
13. Improved table display in r by c chi-square.
14. Expanded help system.

Version 1.9.15 (5th May 2002)

1. Added diversity indices and their bootstrap confidence intervals.
2. Added bias indicator statistics (Egger et al., Begg & Mazumdar) to meta-analysis functions.
3. Added greater choice of bias detection plot to meta-analysis functions.
4. Enhanced bootstrap confidence intervals for Gini coefficient to give BCa.
5. Enhanced dummy variable function.
6. Added scanning for classifier predictors in muliple regression.
7. Fixed graphics problem with Japanese settings in Windows.
8. Fixed problem with certain combinations of classifier predictors in Cox regression.
9. Help updates.

Version 1.9.14 (1st March 2002)

1. More efficient use of computer memory when using multiple workbooks with many data.
2. Expanded measures of association in 2 by 2 table chi-square analysis.
3. Improved display of Cramér's V.

Version 1.9.12 (12th February 2002)

1. Improved handling of extreme values in NNT, odds ratio confidence intervals and diagnostic testing.
2. Updated installer with Windows XP extensions.
3. Added balanced allocation option to intervention-control pair randomisation.
4. Added bootstrap bias-corrected confidence interval estimation to logistic regression.
5. Improved support for non-Western character sets.
6. Extended number needed to treat (NNT) calculations and improved presentation.
7. Added F, chi-square, Student t and uniform (a to b) random number generators.
8. Improved evaluation of two sided binomial probabilities.
9. Enhanced box & whisker plot.
10. Permitted confidence interval calculation for likelihood ratios with sensitivity of zero.
11. Improved handling of missing data.
12. Added Gini coefficient of inequality with bootstrap confidence intervals and Lorenz plots.

Version 1.9.8 (1st September 2001)

1. Changed classification rules in logistic regression to consensus method.
2. Improved data selection by group identifier in grouped regression (covariance).
3. Grouped regression plot added to covariance analysis.
4. Correction to normal plot of residuals in multiple linear regression.
5. Added sample size to t-test outputs.
6. Added variance inflation factor to multiple linear regression.
7. Crosstabs updated to sort categories in anticipation of ordinal analysis.

Version 1.9.7 (1st August 2001)

1. Extended Cronbach alpha to add a standardised version.
2. Added a confidence interval to Cronbach alpha.
3. Removed cells padded with spaces from the end of generated data columns of unequal lengths.
4. Reworked diagnostic test function with confidence intervals for all statistics.
5. Added Goodman-Kruskal gamma to r by c chi-square and crosstabs.
6. Added Kendall tau-b to r by c chi-square and crosstabs.
7. Corrected problem using group identifier data selection method in frequency analysis.

Version 1.9.5 (1st June 2001)

1. Added exact calculations for stratified odds ratios.
2. Added exact calculations for stratified rate ratios.
3. Added Breslow-Day homogeneity statistic to odds-ratio meta-analysis.
4. Extended F quantile calculation to handle larger degrees of freedom.
5. Extended single proportion test to handle very large denominators.
6. Added conditional maximum likelihood methods to single odds ratio analysis.
7. Added conditional maximum likelihood methods to single rate ratio analysis.
8. Added exact analysis of hazard ratio to log-rank test.
9. Improvement to categorical data selection.
10. Added lognormal random deviates.
11. Help updates.

Version 1.9.3 (17th April 01)

1. Added exact Poisson confidence intervals for rates.
2. Added direct standardization of rates.
3. Collected rate functions into a menu group.
4. Improved presentation of rate functions.
5. Extended data input range for sample size calculations.
6. Updated installation system.
7. Help updates.

Version 1.9.2 (4th April 01)

1. Added mid-P values to expanded Fisher's exact test.
2. Improved calculation of binomial probabilities.
3. Improved factorial and log factorial functions in calculator.
4. MS Visual Studio service pack 5 applied.

Version 1.9.1 (11th March 01)

1. Improved interfaces for handling categorical data.
2. Improved axis scaling for ranges that include zero.
3. Improved presentation of survival plots.
4. Help updates.

Version 1.9.0 (1st March 01)

1. Added support for text-based categorical input data.
2. Updated licence key mechanism to cope with an uncommon Windows error in some non-English settings.
3. Improved axis scale presentation.
4. Improved spreadsheet component.
5. Improved selection of worksheet destinations.
6. Updated Spearman rank correlation to cope with very large samples.
7. Correction to intra-class correlation coefficient.
8. Enhanced monitor for long running calculations.
9. Help updates

Version 1.8.10 (9 February 01)

1. Updated licence key mechanism to cope with an uncommon Windows error in some non-English settings.

Version 1.8.9 (21 January 01)

1. Extended the two sample t test to cope with unequal variances.
2. Fixed rare persistence of licence key request loop.

Version 1.8.8 (11 January 01)

1. Corrected rare transposition of observed and reciprocal odds ratios with unusual data.
2. Improved support for far Japanese versions and settings of Windows.
3. Correction to search & replace.

Version 1.8.6 (29 December 00)

1. Improved reference range calculation with option for conservative quantile interval.
2. Improved quantile confidence interval with option to force conservative coverage.
3. Help system updates.
4. Improved precision for Poisson distribution evaluation.
5. Confidence limit option for Poisson parameter added to distribution functions.
6. Poisson inverses added to distribution functions.

Version 1.8.5 (15 December 00)

1. Improved support for international settings of Windows that do not use point as a decimal separator.

Version 1.8.4 (11 December 00)

1. Improved t quantile calculation.
2. Update to sample size calculation for t tests.
3. Help system updates.
4. Updated installation system.

Version 1.8.2 (1 December 00)

1. Constant addition option added to transformations where appropriate.
2. Q-Q plot in agreement analysis improved.
3. Help system improvements.
4. Expanded residual analysis in Cox regression.
5. Popup edit menus added to intermediate results windows.
6. Corrections to calculator/expression-evaluator.

Version 1.8.0 (16 November 00)

1. Added an exact test of independence in r by c tables.
2. Help system improvements.
3. Extended box and whisker plots to optionally show parametric descriptive statistics.
4. Fixed copy and paste on Ctrl+C/V in interactive contingency tables.
5. Updated installation system.

Version 1.7.7 (29 October 00)

1. Fixed problem with use of decimal separators other than ".", such as "," in the German setting.

Version 1.7.6 (27 October 00)

1. Added confidence interval for R in multiple linear regression ANOVA with a single predictor.
2. Help system improvements.
3. Improvements to report editor.
4. Support for infinite risk and confidence limits added to matched pairs contingency tables.
5. Steel-Dwass-Critchlow-Fligner multiple comparison method added to Kruskal-Wallis test.
6. Improved presentation of multiple contrasts in the Friedman test.
7. Improved Excel link.
8. Improved presentation of infinite odds ratios with confidence intervals.
9. Fixed a rare bug of keyboard locking when typing fast with some interactive tests.
10. Installation system upgraded to Wise InstallMaster 8.11.

Version 1.7.4 (17 September 00)

1. Workbook edit menu and navigation items (e.g. Ctrl+F to find) now available when selecting data.
2. Incidence rate ratio meta-analysis updated; re. pooled chi-square for fixed effects.
3. Clear missing data function added to the data menu.
4. Help system improvements.

Version 1.7.3 (10 September 00)

1. Update core system components (Microsoft Visual Studio Service Pack 4).
2. Update install routines (Wise InstallMaster 8.1).
3. Help system improvements.
4. Logistic regression now permits display of results from saturated models.
5. Option for user-defined bins in histograms added.
6. Phi coefficient added to r by c chi-square.
7. Sample size calculation examples added to help.
8. Printing just a selection of text from reports; intermittent bug resolved.
9. Copying text from reports; removal of help context codes improved.
10. Ladder plot; now rejects missing data.
11. Forest plot; stratum labels can now be placed anywhere in a worksheet.
12. Added solid grey shading option to population pyramid plot.
13. Print preview in reports now permits preview of selections.
14. New software numbering scheme as version.update.build (month year).
15. Rare error in logical expression evaluation with "or" corrected.
16. Data_Extract Variables function added.

Version 1.617 release 2000-12 (9 June 00)

1. Improved network installation.
2. Update to Mantel-Haenszel with zero frequencies.
3. Help system improvements.

Version 1.616 release 2000-12 (25 May 00)

1. Sample size estimation for survival analysis added.
2. Improved licence key management for networks.
3. Help system improvements.
4. Interface improvements.

Version 1.615 release 2000-12 (7 May 00)

1. Improved memory management in workbooks.
2. Correction to histogram scaling.
3. Help system improvements.
4. Update to crossover ANOVA.
5. Update to analysis of covariance.

Version 1.612 release 2000-11 (21 April 00)

1. Updated Friedman test presentation and expanded results.
2. Help on Cochrane Q test added to help for Friedman test.
3. Maxwell's chi-square test for k paired data added to inter-rater agreement.
4. Scott's pi coefficient extended to k categories in inter-rater agreement.
5. Improved presentation of inter-rater agreement.
6. Confidence intervals for Kendall's tau(-b) statistic added.
7. Gamma coefficient added to Kendall's rank correlation.

Version 1.611 release 2000-10 (7 April 00).

1. Wise Solutions Inc. corrected a problem with their web based installer.
2. Wise Solutions Inc. corrected a problem with installation on Windows 2000.
3. Residual plots with all regressions improved.
4. New diagnostic plots and statistics (inc. Hosmer-Lemeshow) in logistic regression.
5. Handling of ungrouped data in logistic regression improved further.
6. Help expansions and updates.
7. Interface enhancements.
8. Worksheet search and replace function enhanced.
9. Updated survival probability estimation with unusual data in Cox regression.
10. Updated presentation of Cox regression results.
11. Updated presentation of logistic regression results.
12. Cochrane plots renamed as "forest (Cochrane) plots".

Version 1.609 release 2000-9 (25 March 00).

1. Covariance analysis updated - can now specify baseline predictor for adjusted outcome means.
2. Minor interface enhancements.
3. Standardization added to data menu ((x-mean)/sd, x/sd and x-mean).
4. Revision to confidence interval label for Wilcoxon signed ranks test with certain data.
5. Updated installer.
6. Updated workbook component.

Version 1.608 release 2000-8 (16 March 00).

1. Updated installer (Wise 8.03) to cure restart issue on some systems.
2. Removed underline from spaces between underlined column headings in reports.
3. Replaced option to specify number at start in life tables and adjusted row alignment for lx.
4. Update to handling of classifier variables in Cox regression.
5. Missing reference range report template added.
6. Updated presentation of Kaplan-Meier results.
7. Updated survival analysis functions to allow any group identifier numbers to be used.
8. Multiple comparison methods in ANOVA revised - including new, uniform presentation.
9. Simplified use of censorship variable in survival analysis.
10. Survival analyses updated to allow grouped data (i.e. > 1 event per time).
11. Upper confidence limit for median survivor function made estimable over wider range.

Version 1.605 release 2000-7 (5 March 00)

1. Updates to installation, including facility for web install across a firewall.
2. Update to Cox regression - copes with more unusual data.
3. Reference range function added to parametric methods section.
4. Quantile confidence interval made slightly less conservative in coverage for certain patterns of data.
5. Blom and expected normal order methods added as options to normal scores.
6. Normal plot updated - now with option of methods for scores (including exact).
7. Simple life table function re-written and enhanced.
8. Correction to ungrouped logistic regression interface.

Version 1.601 release 2000-6 (21 February 2000)

1. New round of algorithm re-validation completed
2. General interface improvements and additions
3. Improvements and additions to help system
4. New graphics scaling mechanism for neater axis labels
5. Many small improvements to graphics
6. Correction to prediction interval in simple linear regression
7. Peto's odds ratio added to meta-analysis
8. Improved presentation and precision of Wei-Lachin test
9. Log-rank and Wilcoxon survival routines re-written and enhanced
10. Improved precision of P calculation for Kendall's statistic
11. Correction of font selection in graphics options
12. Improved printing from reports and workbooks
13. Improved presentation of manipulated data
14. Normal scores now van der Waerden

Version 1.505 release 2000-5 (1 January 2000)

1. Expanded Cox regression
2. Selective cell and row delete added to data search facility
3. Improvements and additions to help system
4. Correction to two tailed Mann-Whitney P values larger than 0.5
5. Enhanced box & whisker and spread plots for up to 40 series
6. Improvements to labelling of plots
7. Correction to Smirnov two sample test with large numbers
8. Various interface improvements
9. New web deploy installation (downloads only the files needed)
10. Installations now authenticated and Windows 2000 compliant

Version 1.5 release 1999-4  (1 December 1999)

1. Expanded help system, more statistical detail and explanation
2. Windows 2000 (pre-release) compliance
3. SMR function updated/expanded
4. Fix to log axis scaling in some meta-analysis plots
5. Support for international decimal number formats
6. More precise standard errors of regression coefficients
7. Correction to Cooks distance in weighted regressions
8. Fixed interface error in linearized estimates
9. Fixed mean order issue in ANOVA multiple contrasts
10. Improved life tables

Version 1.5 release 1999-3  (31 October 1999)

1. Help update with correction of linkage with menu items
2. Right click edit menus added to reports and workbooks
3. Text to numbers function enhanced with user-defined substitution table
4. Occasional workbook save problem resolved
5. Improved context sensitive help resolution in reports
6. Improved printing from workbooks (better area definition) 7. Improved printing from reports (help codes removed)