Sample Size for Matched Case-control Studies

 

Menu location: Analysis_Sample Size_Matched Case-Control.

 

This function gives you the minimum sample size necessary to detect a true odds ratio OR with power POWER and a two sided type I error probability ALPHA. If you are using more than one control per case then this function also provides the reduction in sample size relative to a paired study that you can obtain using your number of controls per case (Dupont, 1988).

 

Information required

 

Practical issues

 

Technical validation

The estimated sample size n is calculated as (Dupont, 1990):

- where α = alpha, β = 1 - power, ψ = odds ratio, ϕ is the correlation coefficient for exposure between matched cases and controls, and Zp is the standard normal deviate for probability p. n is rounded up to the closest integer.

 

 

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